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Stellar Activ-Folate is unique in that it contains a 3rd generation methylated folate called Active ExtraFolate-S, that does not need to be broken down by the body prior to use as compared to synthetic folic acid which requires a long slow metabolic break down process. Active ExtraFolate-S is 7 times more bioavailable than synthetic folic acid. Stellar Activ-Folate can be used prior to conception, throughout pregnancy or together with any folate depleting medications such as oral contraceptives, anti-depressants, anti-convulsants or methotrexate.